ASTM E1482-2004 杀病毒剂功效评价中杀病毒剂中和作用的标准试验方法

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【英文标准名称】:StandardTestMethodforNeutralizationofVirucidalAgentsinVirucidalEfficacyEvaluations
【原文标准名称】:杀病毒剂功效评价中杀病毒剂中和作用的标准试验方法
【标准号】:ASTME1482-2004
【标准状态】:现行
【国别】:
【发布日期】:2004
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:E35.15
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:生物危害;保健;灭菌;病毒
【英文主题词】:cytotoxicity;disinfectant;gelfiltration;neutralization;tissueculture;virucidal;virucidalneutralizationmethod
【摘要】:Thistestmethodistobeusedfortheremovalofvirucidalagentsfromagent-virusmixtures,orfromagent-neutralizer-virusmixtures,afterthecontactperiodandbeforetheinoculationofthesemixturesintohostsystemsforassayofinfectivity.Thepurposeofthetestmethodistoreducetheconcentrationofagentsandneutralizersinordertopermittheevaluationofviralinfectivityatdilutionsthatwouldotherwisebetoxictothehost.Thetestmethodisapplicabletothetestingofliquidandpressurizeddisinfectantproducts.Thistestmethodiscompatiblewithorganicsoilloads,hardwater,disinfectantscontainingorganicsolvents,andchemicalneutralizers.1.1Thistestmethodcoverstheuse,inconjunctionwithevaluationsofthevirucidalefficacy,ofdisinfectantsolutionsorpressurizeddisinfectantsprayproductsintendedforuseoninanimatenonporousenvironmentalsurfacesorforotherspecialapplications.Thetestmethodmaybeemployedwithallvirusesandhostsystems.1.2Thistestmethodshouldbeperformedonlybypersonstrainedinmicrobiologyandvirology.1.3Thistestmethodutilizesgelfiltrationtechnology.Theeffectivenessofthetestmethodisdependentontheratioofgelbedvolumetosamplesizeanduniformityinthepreparationofcolumnsandcentrifugationconditions.Theeffectivenessofthistestmethodismaximizedbyinvestigatorpracticeandexperiencewithgelfiltrationtechniques.1.4Thistestmethodwillreduce,butnotnecessarilyeliminate,disinfectanttoxicitywhilepreservingthetiterofinputvirus.1.5ThevaluesstatedinSIunitsaretoberegardedasthestandard.Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.
【中国标准分类号】:C12
【国际标准分类号】:
【页数】:3P.;A4
【正文语种】: